It appears to be becoming established that the causes of these disorders may be due to immunological disturbance of the intestinal mucous membrane.
As a consequence of a variety of factors (stress, surgery, long-term or repeated use of antibiotics, immune shock to a neighbouring organ: liver, spleen, with consequences such as hepatitis, parasitic diseases, etc.), the mucous membrane becomes immuno-incompetent.  The loss of balance leads to a reactive mode common to all mucous membranes, which is inflammation, hypersecretion (mucus), oedema with pain, spasms, bloating or bleeding with eczema-like lesions in Crohn’s disease or ulcerous / hemorrhagic ones in proctocolitis.
It must be stressed that the intestine plays an extremely important role in general immune balance, which is responsible, in particular, for autoimmune diseases.  Imbalance here, with changes to the intestinal ecosystem, may lead to changes at a distance in the balance of other mucous membranes (rhinosinusitis, asthma and bronchitis, recurrent urinary or genital infections with repeated cystitis, or eczema-type skin diseases).
Ailments of this type may have their origins in the intestinal immune imbalance known as “DYSBIOSIS”, and they are probably aggravated by a deficient modern diet and its additional pollution sources (poisoning with heavy metals, organophosphates, benzopyrenes …)

It must also be remembered that the intestine plays a fundamental role, acting as a “conveyor belt between the external and internal environments,” since it allows the exchange and passage of elements from the diet into the bloodstream, transforming them into trace elements, vitamins, and minerals that are bioavailable to the organism for synthesis, particularly in connection with liver function, hormones, chemical mediators and vitamins needed for the functioning of various organs: (brain: production of serotonin, noradrenalin, dopamine; thyroid: production of FT3 and FT4; bone: parathormone, calcium, vitamin D; ovaries: oestrogen-progesterone balance).  This process is begun in the intestine by chemical precursors vital to the hormone synthesis production chain.  Thus, dysfunction in the immune balance of the colon’s mucous membrane, through endogenous deficiency, may produce disease at a distance such as depression, thyroid disorders, and problems of hormonal balance in women (mastosis, menopause, etc.) or bone disorders (abnormally developed arthritis, osteoporosis).  Furthermore, these related problems can often be observed in the same patient because of their common origin.

With regard to treatment, before contemplating replacement therapy with hormone supplements or chemical mediators (thyroid hormones, oestrogens, progesterone, anti-depressants, calcium therapy, which are the usual treatments for this type of disease), we should stimulate endogenous production for the organism as a whole, starting with the intestinal mucous membrane.  Immune stimulation of the intestinal mucous membrane will reinforce the immune function of cells to optimise self-regulation of mucous membrane function, as well as regenerating it for better reconstruction (important role of vitamin B5, magnesium, sulphur, zinc - nickel - cobalt, manganese, and copper).
Treatment will consist of reinforcing the colon’s immune defences by meso-vaccination, mainly administered intradermally, as this offers the best immunogenic effect.  (We have known since Pasteur, that vaccines should be administered by this route in order to be effective.)  Regeneration of the intestinal mucous membrane by vitamins and trace elements helps to maintain a good, permanent, self-regulatory balance of the intestinal mucous membrane with the aim of maintaining good general functioning of the organism.
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